The National Gallery of Umbria (GNU) is home to one of the main art collections in Italy and is housed on the upper floors of the Palazzo dei Priori in Perugia, the seat of the Municipality since medieval times and a significant example of Gothic civil architecture.  

On June 4, 1863, the museum was separated from the academy to become a civic art gallery, dedicated to one of the city's greatest artistic glories, Pietro Vannucci known as Perugino. 

Ten years later, the entire collection was transferred to the Palazzo dei Priori. 

In 1918, it passed to the State and took the name of Royal Vannucci Gallery, later becoming the National Gallery of Umbria. Over the years, the entire complex of Palazzo dei Priori has undergone several renovations and functional upgrades. 

The museum itinerary of the National Gallery of Umbria, inaugurated in its current form in 2006, covers an area of 4000 square meters on two floors. The collection, arranged chronologically, is rich in important works from the Middle Ages and the Renaissance by artists such as Arnolfo di Cambio, Nicola and Giovanni Pisano, Duccio, Gentile da Fabriano, Fra Angelico, Benozzo Gozzoli, Giovanni Boccati, and Piero della Francesca, of which the large altarpiece of St. Anthony with the famous Annunciation in the lunette is preserved. 

Special attention is given to Umbrian artists Benedetto Bonfigli, Bartolomeo Caporali, Fiorenzo di Lorenzo, Perugino, Pinturicchio and their students and followers. 

The National Gallery of Umbria also dedicates some thematic sections to goldsmithing, ivory and wood carvings, traditional “Perugian tablecloths” and the topography of the city of Perugia. 

The itinerary is completed with valuable pictorial testimonies ranging from the seventeenth to the nineteenth century, by Orazio Gentileschi, Valentin de Boulogne, Pietro da Cortona, Sassoferrato, Francesco Trevisani, Sebastiano Conca, Pierre Subleyras, Corrado Giaquinto, Jean-Baptiste Wicar.

The museum spaces also include a well-equipped conference room, a classroom, and the vast Podiani Hall, used for temporary exhibitions, concerts, and performances.