Galleria Spada in Rome houses the important collection of Baroque paintings created during the 17th century by the cardinals Bernardino and Fabrizio Spada. The refinement of its art collection, still displayed on overlapping shelves as in a 17th-century gallery, gives this place a unique charm, accentuated by its characteristic dimension as a precious family collection.

Galleria Spada is located in one of the most beautiful buildings in Rome, the 16th-century Palazzo Capodiferro. In four original rooms, works by famous artists such as Titian, Guido Reni, or Artemisia Gentileschi are exhibited, along with a more detailed overview of Italian 17th-century painting, represented, for example, by Guercino, Pietro Testa known as il Lucchesino, or Giovanni Battista Gaulli, showcased through some of their highest achievements.

In the rooms of Galleria Spada, it is also possible to trace the history of painting genres, such as portraiture, expressed through the works of Bartolomeo Passerotti and Prospero Fontana, or landscape painting, with works ranging from the late 16th century to the early 18th century, including names like Nicolò dell’Abate, Dughet, and Van Lint.

Italian and European Caravaggesque painting is extensively represented in the museum's last room, with absolute masterpieces by Orazio Gentileschi and Michelangelo Cerquozzi, and with a wide collection ranging from Borgianni to Baglione, Cavarozzi, and Mattia Preti, as well as all the trends of European Caravaggism, such as the French one, expressed by Regnier, Tournier, and Valentin de Boulogne, or the Northern one by Van Laer and Van Somer.

A collection of archaeological works, displayed in the ancient style on 17th-century decorated wooden stools or extraordinary carved and gilded baroque wall tables, completes the collection.

At the end of the first-floor museum tour, visitors can explore the Secret Garden, which houses Rome's most spectacular Baroque artifice, the Illusionistic Colonnade (or Perspective) created in 1653 by Francesco Borromini for Cardinal Bernardino Spada.