The collection housed in the seventeenth-century Palazzo Santi boasts a series of precious polychrome terracotta (XI-XVI century) and an extraordinary nucleus of sculptures, which includes wooden works, in terracotta, stucco and stone dating back to between the XIII and the XV centuries, rare evidence of the medieval heritage of sacred art. Of particular note is the Madonna di Poggioprimocaso , a monumental example of the flourishing local production of polychrome wooden madonnas. The collection is ideally completed with the statue of Tobias and the Angel , from the Marche school, exhibited in a reliquary in the choir of the Church of Sant'Antonio Abate.

Starting from the 13th century, Umbrian churches were enriched with sculptures made directly or influenced by sculptors from northern Europe. In the following centuries, Umbrian sculpture follows the ways of that of Abruzzo, whose main features are the accentuated archaicism of expression, the frontal vision of the image and the expressiveness of the faces. These elements are widely found in the sculptures of Cascia.