The Museo del Lapidario di Urbino is home to a rich epigraphic collection divided into two main sections: the first dedicated to artifacts from Rome including relief urns, inscribed slabs, figurative pieces, and brick stamps; the second, in addition to epigraphic material, also gathers statuary pieces. Here, one can find inscribed marble bases, sepulchral inscriptions, statues, and bas-reliefs. The tombstones are displayed on 22 mirrors along the walls, and other types of artifacts are arranged within the other five rooms in the museum.

In addition to the epigraphs that constitute the central nucleus of the collection, it is worth noting the relief in purple porphyry depicting the episode of Ulysses and the sirens, and the slab of the marmorarius Eutropus.