The museum, open to the public in 1981, is housed in the sixteenth century Palazzo Panichi overlooked Piazza Arringo in the historic center of Ascoli Piceno. The museum is divided into three sections with a chronological path that winds through the three floors of the building. Through the exhibits of the rich civic collection of Ascoli, created in 1865 on the basis of the eighteenth donation Mazzoni Bishop, and findings from recent excavations provides a Ascoli territory extraordinary archaeological overview and highlights the unique characteristics of the southern Piceno.
the visit begins on the second floor where are finds from prehistoric complex from the Paleolithic to the Bronze Age. Particularly interesting is the dedicated exposure, on the first floor, the artifacts from picena of age complexes, illustrating the plurality and peculiarities of the cultural aspects of this area in the first millennium B.C. The ground floor, which also includes remains of ancient walls musealizzate on-site, home to the Roman remains. The visit ends with a visit to the nearby picnic area on the ground floor of the Palazzo dei Capitani, overlooking the beautiful Piazza del Popolo, and a visit to the still visible Roman monuments like the Theater and the Twin Gate, in some cases incorporated in the posterior structures such as the Temple whose structures are readable in the perimeter walls of the Church of San Venanzio.