The Museum Complex of the Pilgrims, in Naples, is just a few steps away from the lower decumanus (Spaccanapoli), in the popular district of Pignasecca, an open-air market area rich in architectural, historical, and artistic sites.

The Museum Complex of the Pilgrims is a place of memory, created to make the remarkable historical, artistic, and architectural heritage collected and preserved from the late sixteenth century to the present day in the historic headquarters of the Archconfraternity accessible to all.

The Most August Archconfraternity and Hospitals of the Holy Trinity of Pilgrims and Convalescents was founded in 1578 and today has about 700 members. The initial commitment to take care of the poor conditions and precarious health of pilgrims, with changing demands of the poorest, has taken on new forms over time. At the beginning of the nineteenth century, the ancient "Hospitale House" became a modern healthcare hospital, and when this was absorbed by the national health system (1970), it was through the popular outpatient clinic "Bernardo Giovino" and the Socio-Educational Center for minors "Fabrizio Pignatelli" that the confreres' adherence to the spirit of service and hospitality, which is the origin and purpose of the Archconfraternity, materialized. In service to the cultural and civil growth of the city, the Archconfraternity promotes and hosts conferences, debates, scientific congresses, and artistic events open to the public.

The Museum Complex of the Pilgrims is a constitutive element of the city's identity: here popular devotion, charitable works, and hospitality, artistic expression have been interacting for centuries with the complex life of the city. It is a living and open cultural production site: venue for exhibitions, conferences, public meetings, concerts, educational activities, social activities.

The Museum Complex of the Pilgrims includes the church of Santa Maria Materdomini (1574), the church of the Most Holy Trinity (1798), a work by Carlo Vanvitelli, enriched by the walnut choir and dome with zecchino gold motifs designed by Giuseppe Astarita and the monumental Holy Land, designed by Giovan Antonio Medrano in the second half of the 18th century.