Once the historic residence of Cardinal Branda Castiglioni (1350-1443), it is now an essential stop to fully understand the cultural depth of one of the most important figures of the 14th and 15th centuries.

Precisely in this building there are the most representative testimonies of his humanist thought, interpreted by the pictorial skills of the Tuscan masters, Masolino da Panicale and Lorenzo di Pietro known as "il Vecchietta", and Lombard artists.

The Cardinal's descendants contributed to enriching this heritage, commissioning family portraits and collecting precious furnishing objects which today join the oldest testimonies.