The Palacio of Monterrey was built at the request of Don Alonso de Acevedo y Zúñiga (1495-1559), third count of Monterrey linked to the city of Salamanca where he owned houses and properties.

The architects who took care of the project were Rodrigo Gil de Hontañón and Fray Martín de Santiago in 1539.

During the construction, many local artists, sculptors, designers and decorators participated but the palace, for economic reasons, was never completed and, despite the many hypotheses, we are not sure how the final result should be. In any case, the most beautiful parts of the building are undoubtedly the fortified towers, the whimsical perforated crest and the fireplaces, the first of which in authentic stone filigree, and the second in French style.

The Palace was incorporated into the Casa d'Alba after the marriage of Catalina de Haro y Guzmán (1672-1733), VIII Countess of Monterrey.

The information available on what the interior of the palace was like is sparse. On 6 May 1929 it was declared an "Architectural-Artistic Monument".