The church of San Fedele was built starting in 1569 by the architect Pellegrino Tibaldi (1527-1596) at the behest of the Jesuits and archbishop Carlo Borromeo, one of the leading reformers of the Catholic Church in the sixteenth century. Finally, Pietro Pestagalli in the nineteenth century finished the facade and built the main altar. The church of San Fedele, after the suppression of the Jesuit order (1773-1814), passed to the care of the canons of the nearby church of Santa Maria della Scala, demolished in that period to make room for the Teatro alla Scala. After the Second World War, San Fedele returned to the Jesuits who started a series of social, cultural and artistic activities still today gathered in the San Fedele Cultural Foundation. The museum itinerary develops in the church of San Fedele and in some surrounding spaces and was inaugurated on 31 December 2014, at the end of a decade of restorations that have affected these environments. It is closely linked to the history of the San Fedele Gallery which began in the 1950s in the Jesuit Foundation of the same name. Artists of the caliber of Carlo Carrà, Mario Sironi and Lucio Fontana collaborated on this experimental site, an expressive laboratory. David Simpson, Mimmo Paladino, Jannis Kounellis, Sean Shanahan, Claudio Parmiggiani and Nicola De Maria are some of the artists interviewed in recent years to reflect on fundamental themes of faith, such as the Apocalypse, the Cross, the heavenly Jerusalem, the ex voto, with works designed for the spaces and spaces of the church.