The altarpiece, the subject of some restoration work after its acquisition, still has the original arched frame decorated with imitation marble and equipped with a double system of capitals. The predella has a decorative grotesque motif framing a central cartouche with the dedicatory inscription (now illegible). In the side panels appear the allegory of Faith and Charity in the form of fake sculptures inserted in a marble aedicule with a shell-like crown.

Raffaellino del Colle, a pupil of Raffaello Sanzio, is the author of this altarpiece. At the top is depicted the transport of the Holy House of Loreto: very particular is the way in which the artist depicts the clouds and the body of the little angels, a typical expression of the current to which he belonged, that of Mannerism. In the foreground San Giacomo and San Filippo and in the background a fantastic landscape. This painting was commissioned by a noble family for a church located in Jesi.