The subject of the painting is taken from the Book of Tobias, in the Old Testament. The young Tobiolo is sent by his poor and blind father to recover some money in a distant place. Accompanying him, in addition to the faithful dog, is the incognito archangel Raphael, a real guardian angel. Behind his advice the big fish is killed that will provide the gall to cure Tobiolo's father from blindness. The theme was particularly dear to the Florentine merchants of the fifteenth century, who often sent their children when they were still teenagers on business trips to be understood also as initiation tests. The panel comes from Florence, where it was located in the church of Orsanmichele. It was painted around 1465-1470 by Piero del Pollaiolo, renowned painter brother of the more famous Antonio. On a river landscape that recedes as far as the eye can see, the imposing figures of the protagonists stand out in the foreground, elegant in their movements and even more in their clothing: the ancient one of the archangel, according to the richest fashion of the time that of Tobiolo. Pollaiolo stands out here for the energetic line of the design and for the ability to realistically render the materiality of the surfaces, from the precious fabrics to the marvelous wings that reveal the divine nature of Raffaele.