With an act dated May 24, 1565, transcribed in the Llibre de Concelleria of the year 1564-1565, the master Antioco Mainas, painter of the city of Cagliari, undertook to paint a retable representing the Virgin and Child for the chapel of the Municipal house of Oristano, flanked by Saints Andrew and John the Baptist, and the five councilors in office for that year, including the councilor in chief, Giovanni Dessì. The document shows that the retable was made up of six compartments and a predella with seven panels. Of the polyptych remain the central table with the Virgin between Saints Andrew and John the Baptist and a Deposition of Christ, formerly of the Piloni collection of Cagliari and now of the University of Cagliari. The Catalan theme of Our Lady of the Counselors is translated by Mainas into modern forms, nourished by the Raphaelesque lesson that the painter from Cagliari was able to assume thanks to the circulation in the Sardinian pictorial workshops of prints and drawings that contributed to the updating of the figurative culture of the Sardinian masters. The monumental forms of the enthroned Virgin and in particular the chubby Child are derived in Mainas from the Holy Family of Raphael, through a print by Marcantonio Raimondi (Renata Serra).