The famous Pala Bottigella by Vincenzo Foppa - originally located in the family chapel in the church of San Tommaso in Pavia - is an extraordinary compositional solution: against the background of a skilful perspective construction of an interior stands a series of characters (saints, blessed, donors) around the Madonna and child. All are defined with extreme naturalness, starting with the Madonna, in an affectionate attitude towards her Child who tries to free himself from the embrace to play with Giovan Matteo Bottigella's headdress. The four saints (Matteo, Giovanni Battista, Stefano, Gerolamo) talk to each other on either side of the throne, while the two patrons (Matteo Bottigella and his wife, Bianca Visconti) are presented to the Virgin respectively by Blessed Dominic of Catalonia, founder of the new hospital. San Matteo di Pavia, and by the blessed Sibillina de 'Biscossi, whose miraculously intact body was found in the altar of the chapel. The four characters are painted in full-length profile, with clothes and jewels that attest to their social status. Foppa's language is characterized by a particular plasticity, an interest in nature and light and the influences of Flemish painting, developed in the sense of a new and solemn spatiality, which amplifies the extraordinary truth of the scenes and characters depicted.