The famous Annunciation (1533 - 1535), one of the Master's absolute masterpieces, was created for the Confraternity of the Merchants of Recanati. The representation of the religious event of the Annunciation is very frequent in the history of art but in this case the connotation attributed to it by Lorenzo Lotto is certainly new and particular, if not revolutionary. The reasons that make this Annunciation unique compared to all the others are essentially two: the singular attitude of the Virgin, who instead of being turned towards the Angel, as per tradition, looks frightened at the viewer seeking almost comfort and consolation, and the presence of a cat, at the center of the scene, a symbol of evil but at the same time also an ironic and ambiguous element, which runs away in fear in the face of the arrival of the Angel sent by God the Father. Noteworthy is the description of the details of the room, clearly of Nordic inspiration.