In a pale and autumnal landscape a line of blind people walk slowly: a ditch awaits them into which they will fall without safety. The Gospel parable - when a blind man leads another, you see them both fall into the ditch - becomes for the great painter the pretext to represent a varied and derelict humanity, investigated with a caricatural detail in which each character assumes a expression conditioned by the position he occupies: tragically frightened the one who is falling into the ditch, dazed and unaware of his last in line. Masterpiece of the mature phase, the thin linen canvas is signed and dated 1568 in the lower left. In the background, in the distance, the church of the village of Pede de Saint - Anne, near Brussels, is depicted. The work has always been considered, together with the Misantropo, one of the masterpieces of the Farnese collection.