Baglione, official artist of the Vatican, sent the canvas from Rome, paid a good 120 scudi. In this work he blends his sixteenth-century and mannerist training with the naturalistic language of Caravaggio: despite the heated hostility between the two, in fact, this work is among the most Caravaggesque of Baglione's production.

When the chapel was rebuilt, in the second half of the seventeenth century, all the paintings already placed on the altars of the first chapel were preserved with the exception of that of Baglione, the only one to be replaced: in its place, in 1671, the Government of the Pio Monte della Misericordia had the Deposition by Luca Giordano exhibited.