Among the most sentimental works of De Mura's vast pictorial production, the painting illustrates the Holy Family resting during the flight into Egypt. The almost bucolic scene focuses only on one side of the composition where the three figures are gathered, who relate to each other with a play of glances. The setting, intimate and serene, is given by the tenuous twilight brightness, reinforced by some points of color: the pink flesh of the child, the usual pink and blue of the Madonna's robe, the ocher of the mantle of Saint Joseph and the red of the cloth under the pillow. Critics have compared the painting to the fresco done by the painter in the church of the Nunziatella, in 1751, which offers a chronological reference point.