The portrait of Anton Giulio Brignole-Sale and that of his wife Paolina Adorno constitute one of the rare examples of en pendant portraits made by Van Dyck still remaining together. With a third painting, depicting Geronima Sale-Brignole with his daughter Aurelia, his mother and sister respectively, they were paid to the painter in 1627 - the final year of his stay in Genoa - for a total of 747 lire. These are probably the last paintings executed by the Flemish in Genoa, the city where he arrived in 1621 as best disciple of Rubens, soon enjoying extraordinary success among the new city nobility who, well aware of the symbolic value of the images and the celebratory message from they conveyed, he competed to be portrayed by the young artist. Anton Giulio Brignole - Sale, inheriting from his maternal grandfather the fief of Groppoli and the related title of marquis, was officially ascribed to the Genoese aristocracy in 1626; the following year, just twenty-two, he was portrayed by Van Dyck on horseback and in a stately pose, until a few years earlier reserved exclusively for sovereigns, which emphatically celebrates his recent social status. The compositional model of this equestrian portrait depends on famous Rubensian examples such as Gio. Carlo Doria (Genoa, Galleria di Palazzo Spinola) and the Duke of Lerma (Madrid, Prado Museum) but the pictorial material with which it is made is quite different from the rich and mellow one of the famous master. The canvas of Palazzo Rosso, in fact, is built with a very rapid execution technique, played by glazing of whites and varnishes but not of "body" colors, which ensures a great effect of matter without there being any real substance, such as typical of the works of the Flemish between 1626 and 1627.