The Pietà Mantegazza - so called because it was attributed by critics for a long time to the Mantegazza brothers, although in recent years it has been brought closer to the workshop of Giovanni Antonio Amadeo - is a relief of the highest technical and formal quality. Antonio and Cristoforo Mantegazza are two very famous personalities of the fifteenth century, engaged in the decoration of the facade and cloisters of the Certosa di Pavia, they are called in 1473 to develop the equestrian statue of Francesco Sforza, later designed by Leonardo. The aedicule of the Pietà was created to decorate the facade of the old S. Matteo Hospital, now corresponding to the front facing Piazza Leonardo of the fifteenth-century Aula of the University of Pavia, where a copy is placed. Inside the relief are inserted the figures of the dead Christ supported on the sepulcher, by Mary on the left and by St. John on the right; that stand out in a small space with the refined frames of the newsstand. The figures are characterized by thick locks of hair, pointed beards, long skinny hands, half-closed eyes and open mouths that seem to scream. The two sculptors create a well-defined prototype with their own physiognomic characters rendered with great realism, which manages to convey a strong feeling of pain, capable of reaching a suggestive dramatic fantasy. The terracotta frame is accompanied, below, by a marble slab with a celebratory inscription, destined for the Hospital of the Pietà, the first name of the foundation of the S. Matteo Hospital. In this capital work of fifteenth-century Lombard sculpture, references to the language ranging from Mantegna to the Ferrarese masters can be recognized, overcoming the limits of narrative custom, and marking a way of making sculpture that achieves effects of great emotional participation.